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Cellosaurus HT93A (CVCL_E331)

[Text version]

Cell line name HT93A
Synonyms HT-93A; HT-93; HT93
Accession CVCL_E331
Resource Identification Initiative To cite this cell line use: HT93A (RRID:CVCL_E331)
Comments Doubling time: ~48 hours (PubMed=9472803); ~50 hours (DSMZ).
Derived from sampling site: Peripheral blood.
Sequence variations ETV6-ABL2 (ETV6-ARG) gene fusion (PubMed=10706884).
PML-RARA gene fusion (PubMed=9472803).
Disease Acute promyelocytic leukemia with t(15;17)(q22;q12) PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): DSMZ; TKG

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81810,13
D7S82011,12
D13S3179,12
D16S5399,11
TH017
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=8690048
Toba K., Kishi K., Koike T., Winton E.F., Takahashi H., Nagai K., Maruyama S., Furukawa T., Hashimoto S., Masuko M., Uesugi Y., Kuroha T., Tsukada N., Shibata A.
Profile of cell cycle in hematopoietic malignancy by DNA/RNA quantitation using 7AAD/PY.
Exp. Hematol. 24:894-901(1996)

PubMed=9472803
Kishi K., Toba K., Azegami T., Tsukada N., Uesugi Y., Masuko M., Niwano H., Hashimoto S., Sakaue M., Furukawa T., Koike T., Takahashi H., Maekawa T., Abe T., Aizawa Y.
Hematopoietic cytokine-dependent differentiation to eosinophils and neutrophils in a newly established acute promyelocytic leukemia cell line with t(15;17).
Exp. Hematol. 26:135-142(1998)

PubMed=10706884; DOI=10.1182/blood.V95.6.2126
Iijima Y., Ito T., Oikawa T., Eguchi M., Eguchi-Ishimae M., Kamada N., Kishi K., Asano S., Sakaki Y., Sato Y.
A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.
Blood 95:2126-2131(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=25373509; DOI=10.3109/10428194.2014.982643
Iriyama N., Hatta Y., Takei M.
ETV6/ARG oncoprotein confers autonomous cell growth by enhancing c-Myc expression via signal transducer and activator of transcription 5 activation in the acute promyelocytic leukemia cell line HT93A.
Leuk. Lymphoma 56:2416-2423(2015)

Cross-references
Cell line collections DSMZ; ACC-735
TKG; TKG 0703
Other Wikidata; Q54896599
Polymorphism and mutation databases Cosmic; 975254
Cosmic; 1281317
Entry history
Entry creation22-Oct-2012
Last entry updated12-Mar-20
Version number12