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Cellosaurus UISO-MCC-1 (CVCL_E996)

[Text version]

Cell line name UISO-MCC-1
Synonyms UISO-MCC 1; UISO-MCC1; UISO-mcc1; UISO; University of Illinois Surgical Oncology-Merkel Cell Carcinoma-1
Accession CVCL_E996
Resource Identification Initiative To cite this cell line use: UISO-MCC-1 (RRID:CVCL_E996)
Comments Doubling time: 64.8 hours (PubMed=8227544); 1.5 days (PubMed=20444890).
Derived from sampling site: Thigh; skin.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line

PubMed=8227544; DOI=10.1016/0190-9622(93)70236-M
Ronan S.G., Green A.D., Shilkaitis A., Huang T.-S.W., Das Gupta T.K.
Merkel cell carcinoma: in vitro and in vivo characteristics of a new cell line.
J. Am. Acad. Dermatol. 29:715-722(1993)

PubMed=10732753; DOI=10.1054/bjoc.1999.1006
Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M., Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R., De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=12209990; DOI=10.1002/ijc.10591
Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S., Cocquyt V., Salwen H.R., De Paepe A., Speleman F.
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Int. J. Cancer 101:137-145(2002)

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:E31255-E31255(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

Chemistry resources GDSC; 1299074
PharmacoDB; UISOMCC1_1640_2019
Other Wikidata; Q54990245
Polymorphism and mutation databases Cosmic; 1693074
Cosmic; 1699814
Entry history
Entry creation22-Oct-2012
Last entry update20-May-2021
Version number13