ID   UISO-MCC-1
AC   CVCL_E996
SY   UISO-MCC 1; UISO-MCC1; UISO-mcc1; UISO; University of Illinois Surgical Oncology-Merkel Cell Carcinoma-1
DR   Cosmic; 1693074
DR   Cosmic; 1699814
DR   GDSC; 1299074
DR   PharmacoDB; UISOMCC1_1640_2019
DR   Wikidata; Q54990245
RX   PubMed=8227544;
RX   PubMed=10732753;
RX   PubMed=12209990;
RX   PubMed=20444890;
RX   PubMed=22363598;
RX   PubMed=23563200;
CC   Doubling time: 64.8 hours (PubMed=8227544); 1.5 days (PubMed=20444890).
CC   Derived from site: In situ; Thigh, skin; UBERON=UBERON_0004262.
DI   NCIt; C9231; Merkel cell carcinoma
DI   ORDO; Orphanet_79140; Cutaneous neuroendocrine carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   46Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 29-06-23; Version: 15
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RX   PubMed=8227544; DOI=10.1016/0190-9622(93)70236-M;
RA   Ronan S.G., Green A.D., Shilkaitis A., Huang T.-S.W., Das Gupta T.K.;
RT   "Merkel cell carcinoma: in vitro and in vivo characteristics of a new
RT   cell line.";
RL   J. Am. Acad. Dermatol. 29:715-722(1993).
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RX   PubMed=10732753; DOI=10.1054/bjoc.1999.1006;
RA   Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M.,
RA   Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R.,
RA   De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.;
RT   "Mutation analysis of P73 and TP53 in Merkel cell carcinoma.";
RL   Br. J. Cancer 82:823-826(2000).
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RX   PubMed=12209990; DOI=10.1002/ijc.10591;
RA   Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S.,
RA   Cocquyt V., Salwen H.R., De Paepe A., Speleman F.;
RT   "Combined karyotyping, CGH and M-FISH analysis allows detailed
RT   characterization of unidentified chromosomal rearrangements in Merkel
RT   cell carcinoma.";
RL   Int. J. Cancer 101:137-145(2002).
//
RX   PubMed=20444890; DOI=10.1128/JVI.02400-09;
RA   Houben R., Shuda M., Weinkam R., Schrama D., Feng H.-C., Chang Y.,
RA   Moore P.S., Becker J.C.;
RT   "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require
RT   expression of viral T antigens.";
RL   J. Virol. 84:7064-7072(2010).
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RX   PubMed=22363598; DOI=10.1371/journal.pone.0031255;
RA   Hafner C., Houben R., Baeurle A., Ritter C., Schrama D.,
RA   Landthaler M., Becker J.C.;
RT   "Activation of the PI3K/AKT pathway in Merkel cell carcinoma.";
RL   PLoS ONE 7:E31255-E31255(2012).
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RX   PubMed=23563200; DOI=10.1038/jid.2013.169;
RA   Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S.,
RA   Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.;
RT   "Mechanisms of p53 restriction in Merkel cell carcinoma cells are
RT   independent of the Merkel cell polyoma virus T antigens.";
RL   J. Invest. Dermatol. 133:2453-2460(2013).
//