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Cellosaurus MCF7-TamR (CVCL_EG55)

[Text version]

Cell line name MCF7-TamR
Accession CVCL_EG55
Resource Identification Initiative To cite this cell line use: MCF7-TamR (RRID:CVCL_EG55)
Comments Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Omics: Deep phosphoproteome analysis.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=26330541; DOI=10.1074/mcp.M115.050484
Wu X., Zahari M.S., Renuse S., Nirujogi R.S., Kim M.-S., Manda S.S., Stearns V., Gabrielson E., Sukumar S., Pandey A.
Phosphoproteomic analysis identifies focal adhesion kinase 2 (FAK2) as a potential therapeutic target for tamoxifen resistance in breast cancer.
Mol. Cell. Proteomics 14:2887-2900(2015)

Other Wikidata; Q54904464
Proteomic databases PRIDE; PXD001812
Entry history
Entry creation13-Jul-2016
Last entry update02-Jul-2020
Version number6