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Cellosaurus BT474-LAPRb (CVCL_EI03)

[Text version]

Cell line name BT474-LAPRb
Accession CVCL_EI03
Resource Identification Initiative To cite this cell line use: BT474-LAPRb (RRID:CVCL_EI03)
Comments Selected for resistance to: ChEBI; CHEBI:49603; Lapatinib (Tykerb; Tyverb).
Sequence variations Heterozygous for MAPK1 p.His61Gln (c.183C>G) (from parent cell line).
Heterozygous for PIK3CA p.Lys111Asn (c.333G>C) (ClinVar=VCV000376483) (from parent cell line).
Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0179 (BT-474)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line

PubMed=26883193; DOI=10.18632/oncotarget.7317
Creedon H., Gomez-Cuadrado L., Tarnauskaite Z., Balla J., Canel M., MacLeod K.G., Serrels B., Fraser C., Unciti-Broceta A., Tracey N., Le Bihan T., Klinowska T., Sims A.H., Byron A., Brunton V.G.
Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.
Oncotarget 7:11539-11552(2016)

Other Wikidata; Q54798496
Entry history
Entry creation13-Jul-2016
Last entry update02-Jul-2020
Version number8