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Cellosaurus ER-SCC-25 (CVCL_EI28)

[Text version]
Cell line name ER-SCC-25
Accession CVCL_EI28
Resource Identification Initiative To cite this cell line use: ER-SCC-25 (RRID:CVCL_EI28)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg209Lysfs*6 (c.626_627delGA); ClinVar=VCV000372539; Zygosity=Heterozygous (from parent cell line).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1682 (SCC-25)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Publications

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008
Stanam A., Love-Homan L., Joseph T.S., Espinosa-Cotton M., Simons A.L.
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

Cross-references
Encyclopedic resources Wikidata; Q54832419
Gene expression databases GEO; GSM1519071
GEO; GSM1519072
GEO; GSM1519073
Entry history
Entry creation26-Sep-2016
Last entry update29-Jun-2023
Version number9