Cellosaurus cell line CCRF-CEM C7H2 (CVCL_EP75)

• Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  
• Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
  

PubMed=7812967
Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L., Fiegl M., Geley S., Kofler R.
Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line.
Cancer Res. 55:348-353(1995)

PubMed=8895760
Geley S., Hartmann B.L., Hala M., Strasser-Wozak E.M.C., Kapelari K., Kofler R.
Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.
Cancer Res. 56:5033-5038(1996)

PubMed=10467407; DOI=10.1038/sj.onc.1202820
Loffler M., Ausserlechner M.J., Tonko M., Hartmann B.L., Bernhard D., Geley S., Helmberg A., Kofler R.
c-Myc does not prevent glucocorticoid-induced apoptosis of human leukemic lymphoblasts.
Oncogene 18:4626-4631(1999)

PubMed=15637111; DOI=10.1096/fj.04-3062fje
Parson W., Kirchebner R., Muhlmann R., Renner K., Kofler A., Schmidt S., Kofler R.
Cancer cell line identification by short tandem repeat profiling: power and limitations.
FASEB J. 19:434-436(2005)