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Cellosaurus 2LMP (CVCL_EQ20)

[Text version]

Cell line name 2LMP
Synonyms 2-LMP
Accession CVCL_EQ20
Resource Identification Initiative To cite this cell line use: 2LMP (RRID:CVCL_EQ20)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Omics: Deep RNAseq analysis.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=9739048; DOI=10.1172/JCI3492
Zhai Y., Guo R., Hsu T.-L., Yu G.-L., Ni J., Kwon B.S., Jiang G.-W., Lu J., Tan J., Ugustus M., Carter K., Rojas L., Zhu F., Lincoln C., Endress G., Xing L., Wang S., Oh K.-O., Gentz R., Ruben S., Lippman M.E., Hsieh S.-L., Yang D.
LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.
J. Clin. Invest. 102:1142-1151(1998)

Cross-references
Gene expression databases GEO; GSM1401670
Other Wikidata; Q54584606
Entry history
Entry creation26-Sep-2016
Last entry update02-Jul-2020
Version number8