Cellosaurus IGROV-1/T8 (CVCL_EQ60)

Cell line name IGROV-1/T8
Synonyms IGROV1/T8; Igrov1 T8; T8
Accession CVCL_EQ60
Resource Identification Initiative To cite this cell line use: IGROV-1/T8 (RRID:CVCL_EQ60)
Comments Selected for resistance to: ChEBI; CHEBI:63632; Topotecan.
Sequence variation: Heterozygous for BRCA1 p.Lys654fs*47 (from parent cell line).
Sequence variation: Heterozygous for SMAD4 p.Gly231fs*10 (from parent cell line).
Sequence variation: Heterozygous for PTEN p.Thr319fs*1 (from parent cell line).
Sequence variation: Heterozygous for TP53 p.Tyr126Cys (from parent cell line).
Omics: Transcriptome analysis.
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Category Cancer cell line

Maliepaard M., van Gastelen M.A., de Jong L.A., Pluim D., van Waardenburg R.C.A.M., Ruevekamp-Helmers M.C., Floot B.G.J., Schellens J.H.M.
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.
Cancer Res. 59:4559-4563(1999)

Scheffer G.L., Maliepaard M., Pijnenborg A.C.L.M., van Gastelen M.A., de Jong M.C., Schroeijers A.B., van der Kolk D.M., Allen J.D., Ross D.D., van der Valk P., Dalton W.S., Schellens J.H.M., Scheper R.J.
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.
Cancer Res. 60:2589-2593(2000)

Maliepaard M., Scheffer G.L., Faneyte I.F., van Gastelen M.A., Pijnenborg A.C.L.M., Schinkel A.H., van De Vijver M.J., Scheper R.J., Schellens J.H.M.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
Cancer Res. 61:3458-3464(2001)

Gene expression databases GEO; GSM851943