ID   A431-PR
AC   CVCL_EQ67
SY   A431 PR
DR   cancercelllines; CVCL_EQ67
DR   GEO; GSM183434
DR   GEO; GSM183435
DR   Wikidata; Q54606915
RX   PubMed=17560336;
CC   Population: Caucasian.
CC   Knockout cell: Method=shRNA knockdown; HGNC; 9588; PTEN.
CC   Sequence variation: Gene fusion; HGNC; 3236; EGFR + HGNC; 9237; PPARGC1A; Name(s)=EGFR-PPARGC1A (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0037 ! A-431
SX   Female
AG   85Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 12
//
RX   PubMed=17560336; DOI=10.1016/j.ccr.2007.04.021;
RA   Vivanco I., Palaskas N., Tran C., Finn S.P., Getz G., Kennedy N.J.,
RA   Jiao J., Rose J., Xie W.-L., Loda M., Golub T.R., Mellinghoff I.K.,
RA   Davis R.J., Wu H., Sawyers C.L.;
RT   "Identification of the JNK signaling pathway as a functional target of
RT   the tumor suppressor PTEN.";
RL   Cancer Cell 11:555-569(2007).
//