Cellosaurus IST-1 (CVCL_F642)

Cell line name IST-1
Accession CVCL_F642
Resource Identification Initiative To cite this cell line use: IST-1 (RRID:CVCL_F642)
Comments Problematic cell line: Contaminated. Shown to be a SK-OV-3 derivative. Originally thought to originate from and HPV16 immortalized first trimester placenta.
Sequence variation: Heterozygous for APC p.Thr1556fs*9 (from parent cell line).
Sequence variation: Heterozygous for PIK3CA p.His1047Arg (from parent cell line).
Sequence variation: Homozygous for TP53 p.Ser90fs*33 (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO10,11,12
D13S3178,11,12
D16S53910,12,13
D5S81811,12
D7S8209,10,13,14
TH017,8,9,9.3
TPOX6,8,9,11
vWA16,17,18
Web pages http://www.atcc.org/support/faqs/8093b/IST1%20ATCC%20CRL2734-1068.aspx
http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=9701564
Shih I.-M., Wang T.-L., Wu T.-C., Kurman R.J., Gearhart J.D.
Expression of Mel-CAM in implantation site intermediate trophoblastic cell line, IST-1, limits its migration on uterine smooth muscle cells.
J. Cell Sci. 111:2655-2664(1998)

Cross-references
Cell line collections ATCC; CRL-2734 - Discontinued
Biological sample resources BioSample; SAMN03151922
BioSample; SAMN03471780