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Cellosaurus KS Y-1 (CVCL_F660)

[Text version]
Cell line name KS Y-1
Synonyms KS Y1; KSY-1
Accession CVCL_F660
Resource Identification Initiative To cite this cell line use: KS Y-1 (RRID:CVCL_F660)
Comments Group: Patented cell line.
Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=22987579). Was thought to originate from the pleural effusion of a male AIDS patient with Kaposi sarcoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00408.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11448.
Population: Caucasian; Swedish.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0554 (T24)
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/ksy-1-atcc-crl-11448
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=7629884; DOI=10.1093/jnci/87.13.974
Lunardi-Iskandar Y., Gill P.S., Lam V.H., Zeman R.A., Michaels F., Mann D.L., Reitz M.S. Jr., Kaplan M.H., Berneman Z.N., Carter D., Bryant J.L., Gallo R.C.
Isolation and characterization of an immortal neoplastic cell line (KS Y-1) from AIDS-associated Kaposi's sarcoma.
J. Natl. Cancer Inst. 87:974-981(1995)

Patent=US5569602
Lunardi-Iskandar Y., Gallo R.C.
First immortalized Kaposi's sarcoma cell line.
Patent number US5569602, 29-Oct-1996

DOI=10.1007/0-306-46861-1_10
Boshoff C.
Kaposi's sarcoma.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.157-166; Kluwer Academic Publishers; New York (1999)

PubMed=22987579; DOI=10.1002/ijc.27849
Sturzl M., Gaus D., Dirks W.G., Ganem D.E., Jochmann R.
Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line.
Int. J. Cancer 132:1954-1958(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_F660
Biological sample resources BioSample; SAMN03151948
Encyclopedic resources Wikidata; Q54900488
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number22