ID   KS Y-1
AC   CVCL_F660
SY   KS Y1; KSY-1
DR   BioSample; SAMN03151948
DR   cancercelllines; CVCL_F660
DR   Wikidata; Q54900488
RX   DOI=10.1007/0-306-46861-1_10;
RX   Patent=US5569602;
RX   PubMed=7629884;
RX   PubMed=22987579;
WW   https://www.atcc.org/en/support/technical-support/faqs/ksy-1-atcc-crl-11448
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Group: Patented cell line.
CC   Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=22987579). Was thought to originate from the pleural effusion of a male AIDS patient with Kaposi sarcoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00408.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11448.
CC   Population: Caucasian; Swedish.
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0554 ! T24
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 22
//
RX   DOI=10.1007/0-306-46861-1_10;
RA   Boshoff C.;
RT   "Kaposi's sarcoma.";
RL   (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.157-166; Kluwer Academic Publishers; New York (1999).
//
RX   Patent=US5569602;
RA   Lunardi-Iskandar Y., Gallo R.C.;
RT   "First immortalized Kaposi's sarcoma cell line.";
RL   Patent number US5569602, 29-Oct-1996.
//
RX   PubMed=7629884; DOI=10.1093/jnci/87.13.974;
RA   Lunardi-Iskandar Y., Gill P.S., Lam V.H., Zeman R.A., Michaels F.,
RA   Mann D.L., Reitz M.S. Jr., Kaplan M.H., Berneman Z.N., Carter D.,
RA   Bryant J.L., Gallo R.C.;
RT   "Isolation and characterization of an immortal neoplastic cell line
RT   (KS Y-1) from AIDS-associated Kaposi's sarcoma.";
RL   J. Natl. Cancer Inst. 87:974-981(1995).
//
RX   PubMed=22987579; DOI=10.1002/ijc.27849;
RA   Sturzl M., Gaus D., Dirks W.G., Ganem D.E., Jochmann R.;
RT   "Kaposi's sarcoma-derived cell line SLK is not of endothelial origin,
RT   but is a contaminant from a known renal carcinoma cell line.";
RL   Int. J. Cancer 132:1954-1958(2013).
//