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Cellosaurus MOLT-4 clone 8 (CVCL_F827)

[Text version]
Cell line name MOLT-4 clone 8
Synonyms Molt-4 Clone 8; Molt-4 clone no.8; MOLT 4 clone 8; Molt 4 clone 8; Molt4 clone 8; Molt4 Clone8; MOLT-4 cl. 8; MOLT-4 cl.8; MOLT-F8; M4Cl8; M4C18; MOLT4/8
Accession CVCL_F827
Resource Identification Initiative To cite this cell line use: MOLT-4 clone 8 (RRID:CVCL_F827)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0013 (MOLT-4)
Children:
CVCL_WU92 (MOLT-4.CCR5)CVCL_S545 (MOLT-4/CCR5)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0052&theme=default
Publications

PubMed=2419583; DOI=10.1128/JVI.57.3.1159-1162.1986
Kikukawa R., Koyanagi Y., Harada S., Kobayashi N., Hatanaka M., Yamamoto N.
Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4.
J. Virol. 57:1159-1162(1986)

Cross-references
Cell line collections (Providers) HIVReagentProgram; ARP-175
Cell line databases/resources cancercelllines; CVCL_F827
Encyclopedic resources Wikidata; Q54906366
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number21