ID   B16-F10-Nex2
AC   CVCL_F942
SY   B16F10-Nex2; B16F10-NEX2; B16F10Nex2; B16Nex2; Nex2
DR   BTO; BTO:0003424
DR   BCRJ; 0342
DR   ChEMBL-Cells; CHEMBL4482994
DR   ChEMBL-Targets; CHEMBL4483228
DR   PubChem_Cell_line; CVCL_F942
DR   Wikidata; Q54752446
RX   PubMed=12470474;
RX   PubMed=15457088;
RX   PubMed=20689762;
CC   Characteristics: Melanotic. Shows low immunogenicity and moderate virulence. Forms subcutaneous tumours which are lethal, but do not metastasize to the lung unless injected intravenously (PubMed=15457088).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Breed/subspecies: C57BL/6.
DI   NCIt; C21790; Mouse melanoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_0159 ! B16-F10
SX   Male
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 29-06-23; Version: 10
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RX   PubMed=12470474; DOI=10.1089/153685902761022661;
RA   Dobroff A.S., Rodrigues E.G., Moraes J.Z., Travassos L.R.;
RT   "Protective, anti-tumor monoclonal antibody recognizes a
RT   conformational epitope similar to melibiose at the surface of invasive
RT   murine melanoma cells.";
RL   Hybrid. Hybridomics 21:321-331(2002).
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RX   PubMed=15457088; DOI=10.1097/00008390-200410000-00002;
RA   Freitas Z.F.O., Rodrigues E.G., Oliveira V., Carmona A.K.,
RA   Travassos L.R.;
RT   "Melanoma heterogeneity: differential, invasive, metastatic properties
RT   and profiles of cathepsin B, D and L activities in subclones of the
RT   B16F10-NEX2 cell line.";
RL   Melanoma Res. 14:333-344(2004).
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RX   PubMed=20689762; DOI=10.1593/tlo.09316;
RA   Dobroff A.S., Rodrigues E.G., Juliano M.A., Moreira D.F.,
RA   Nakayasu E.S., Almeida I.C., Mortara R.A., Jacysyn J.F.,
RA   Amarante-Mendes G.P., Magliani W., Conti S., Polonelli L.,
RA   Travassos L.R.;
RT   "Differential antitumor effects of IgG and IgM monoclonal antibodies
RT   and their synthetic complementarity-determining regions directed to
RT   new targets of B16F10-Nex2 melanoma cells.";
RL   Transl. Oncol. 3:204-217(2010).
//