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Cellosaurus HCC60 (CVCL_G002)

[Text version]

Cell line name HCC60
Synonyms HCC0060
Accession CVCL_G002
Resource Identification Initiative To cite this cell line use: HCC60 (RRID:CVCL_G002)
Comments Problematic cell line: Contaminated. Shown to be a NCI-H23 derivative (PubMed=25877200). Originally thought to originate from a 26 year old female patient with an ovarian cystadenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00533.
Population: African American.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Derived from sampling site: Lung.
Sequence variations Homozygous for ATM p.Gln1919Pro (c.5756A>C) (ClinVar=VCV000580726) (from parent cell line).
Heterozygous for KRAS p.Gly12Cys (c.34G>T) (ClinVar=VCV000012578) (from parent cell line).
Homozygous for STK11 p.Trp332Ter (c.996G>A) (ClinVar=VCV000376339) (from parent cell line).
Homozygous for TP53 p.Met246Ile (c.738G>C) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1547 (NCI-H23)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D3S135815
D5S81812,13
D7S8209,10
D8S117915
D13S31712
D16S53911
D18S5114
D21S1130
FGA24
Penta D8
Penta E7,17
TH016
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=12429618
Rathi A., Virmani A.K., Schorge J.O., Elias K.J., Maruyama R., Minna J.D., Mok S.C., Girard L., Fishman D.A., Gazdar A.F.
Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women.
Clin. Cancer Res. 8:3324-3331(2002)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Ontologies EFO; EFO_0006418
Biological sample resources BioSample; SAMN03473068
Chemistry resources PharmacoDB; HCC60_507_2019
Gene expression databases ArrayExpress; E-MTAB-2706
Other Wikidata; Q54881769
Polymorphism and mutation databases Cosmic; 1113279
Entry history
Entry creation11-Feb-2013
Last entry update29-Oct-2020
Version number18