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Cellosaurus 1259-mel (CVCL_GR81)

[Text version]
Cell line name 1259-mel
Synonyms 1259-MEL; 1259mel; 1259MEL
Accession CVCL_GR81
Resource Identification Initiative To cite this cell line use: 1259-mel (RRID:CVCL_GR81)
Comments From: Rosenberg S.A.; Surgery Branch, National Cancer Institute, National Institutes of Health; Bethesda; USA.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Unspecified (PubMed=15661905).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=8537970; DOI=10.1093/jnci/88.2.100
Restifo N.P., Marincola F.M., Kawakami Y., Taubenberger J.K., Yannelli J.R., Rosenberg S.A.
Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy.
J. Natl. Cancer Inst. 88:100-108(1996)

PubMed=15661905; DOI=10.4049/jimmunol.174.3.1462
Chang C.-C., Campoli M., Restifo N.P., Wang X.-H., Ferrone S.
Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.
J. Immunol. 174:1462-1471(2005)

Cross-references
Cell line databases/resources TOKU-E; 4040
Encyclopedic resources Wikidata; Q54581206
Polymorphism and mutation databases Cosmic; 2759882
Entry history
Entry creation26-Sep-2016
Last entry update29-Jun-2023
Version number9