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Cellosaurus SGBS (CVCL_GS28)

Cell line name SGBS
Synonyms Simpson Golabi Behmel Syndrome cell strain
Accession CVCL_GS28
Resource Identification Initiative To cite this cell line use: SGBS (RRID:CVCL_GS28)
Comments Characteristics: Has a capacity for adipogenic differentiation. Once differentiated, the cells function and behave as mature adipocytes.
Omics: Deep quantitative proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Adipose tissue; UBERON=UBERON_0001013.
Cell type: Stromal cell; CL=CL_0000499.
Disease Simpson Golabi Behmel syndrome type 1 (NCIt: C118787)
Simpson-Golabi-Behmel syndrome (ORDO: Orphanet_373)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3M
Category Finite cell line

PubMed=11244452; DOI=10.1038/sj.ijo.0801520
Wabitsch M., Brenner R.E., Melzner I., Braun M., Moller P., Heinze E., Debatin K.-M., Hauner H.
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation.
Int. J. Obes. 25:8-15(2001)

PubMed=20054179; DOI=10.1159/000145784
Fischer-Posovszky P., Newell F.S., Wabitsch M., Tornqvist H.E.
Human SGBS cells -- a unique tool for studies of human fat cell biology.
Obes. Facts 1:184-189(2008)

PubMed=22645513; DOI=10.3389/fendo.2011.00089
Keuper M., Dzyakanchuk A., Amrein K.E., Wabitsch M., Fischer-Posovszky P.
THP-1 macrophages and SGBS adipocytes -- a new human in vitro model system of inflamed adipose tissue.
Front. Endocrinol. 2:89.1-89.8(2011)

PubMed=25925588; DOI=10.1186/s12967-015-0480-6
Guennoun A., Kazantzis M., Thomas R., Wabitsch M., Tews D., Seetharama Sastry K., Abdelkarim M., Zilberfarb V., Strosberg A.D., Chouchane L.
Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype.
J. Transl. Med. 13:135.1-135.18(2015)

Chemistry resources ChEMBL-Cells; CHEMBL4482992
ChEMBL-Targets; CHEMBL4483278
PubChem_Cell_line; CVCL_GS28
Encyclopedic resources Wikidata; Q54953168
Gene expression databases GEO; GSM1543665
GEO; GSM1543666
GEO; GSM1543667
Proteomic databases PRIDE; PXD000012
PRIDE; PXD006341
PRIDE; PXD023227
PRIDE; PXD023266
Entry history
Entry creation26-Sep-2016
Last entry update29-Jun-2023
Version number9