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Cellosaurus BR (CVCL_GT42)

[Text version]
Cell line name BR
Synonyms BRMCT
Accession CVCL_GT42
Resource Identification Initiative To cite this cell line use: BR (RRID:CVCL_GT42)
Comments Doubling time: 36 hours (PubMed=27257868).
Omics: Deep exome analysis.
Sequence variations
  • Mutation; VGNC; 42422; KIT; Simple; p.Leu575Pro (c.1724T>C); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 46054; SETD2; Simple; p.Arg526fs (c.1576delA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Ala193Asp (c.578C>A); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; 47719; TP53; Simple; p.Arg263Cys (c.787C>T); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine mastocytoma (NCIt: C129077)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=31175136

Markers:
Dog FHC2010227,235
Dog FHC2054180
Dog FHC2079279
Dog PEZ1111,119
Dog PEZ12270,274
Dog PEZ20176,180
Dog PEZ3121,134
Dog PEZ5103,109
Dog PEZ6180,184
Dog PEZ8228,242

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Publications

PubMed=1634619; DOI=10.1172/JCI115853
Pennington D.W., Lopez A.R., Thomas P.S., Peck C., Gold W.M.
Dog mastocytoma cells produce transforming growth factor beta 1.
J. Clin. Invest. 90:35-41(1992)

PubMed=9646437; DOI=10.1016/S0165-2427(97)00166-9
Garcia G., Brazis P., Majo N., Ferrer L., de Mora F., Puigdemont A.
Comparative morphofunctional study of dispersed mature canine cutaneous mast cells and BR cells, a poorly differentiated mast cell line from a dog subcutaneous mastocytoma.
Vet. Immunol. Immunopathol. 62:323-337(1998)

PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7
London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C., Geissler E.N.
Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit.
Exp. Hematol. 27:689-697(1999)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54798117
Entry history
Entry creation26-Sep-2016
Last entry update21-Mar-2023
Version number8