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Cellosaurus MCF-7/C4-12 (CVCL_GX99)

[Text version]

Cell line name MCF-7/C4-12
Synonyms MCF-7 C4-12; MCF7 C4-12; MCF-7:C4-12; MCF-7C4-12; C4-12
Accession CVCL_GX99
Resource Identification Initiative To cite this cell line use: MCF-7/C4-12 (RRID:CVCL_GX99)
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11479214
Oesterreich S., Zhang P., Guler R.L., Sun X., Curran E.M., Welshons W.V., Osborne C.K., Lee A.V.
Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth.
Cancer Res. 61:5771-5777(2001)

Cross-references
Cell line databases/resources TOKU-E; 4086
Other Wikidata; Q54904358
Entry history
Entry creation26-Sep-2016
Last entry update02-Jul-2020
Version number6