ID   MCF-7/C4-12
AC   CVCL_GX99
SY   MCF-7 C4-12; MCF7 C4-12; MCF-7:C4-12; MCF-7C4-12; C4-12
DR   cancercelllines; CVCL_GX99
DR   TOKU-E; 4086
DR   Wikidata; Q54904358
RX   PubMed=11479214;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 12
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RX   PubMed=11479214;
RA   Oesterreich S., Zhang P., Guler R.L., Sun X.-H., Curran E.M.,
RA   Welshons W.V., Osborne C.K., Lee A.V.;
RT   "Re-expression of estrogen receptor alpha in estrogen receptor
RT   alpha-negative MCF-7 cells restores both estrogen and insulin-like
RT   growth factor-mediated signaling and growth.";
RL   Cancer Res. 61:5771-5777(2001).
//