ID   T47D:C4
AC   CVCL_GY02
DR   cancercelllines; CVCL_GY02
DR   Wikidata; Q54971581
RX   PubMed=2224859;
RX   PubMed=2632259;
RX   PubMed=8883409;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0553 ! T-47D
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 11
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RX   PubMed=2224859;
RA   Murphy C.S., Pink J.J., Jordan V.C.;
RT   "Characterization of a receptor-negative, hormone-nonresponsive clone
RT   derived from a T47D human breast cancer cell line kept under
RT   estrogen-free conditions.";
RL   Cancer Res. 50:7285-7292(1990).
//
RX   PubMed=2632259; DOI=10.1016/0277-5379(89)90348-9;
RA   Murphy C.S., Meisner L.F., Wu S.-Q., Jordan V.C.;
RT   "Short- and long-term estrogen deprivation of T47D human breast cancer
RT   cells in culture.";
RL   Eur. J. Cancer Clin. Oncol. 25:1777-1788(1989).
//
RX   PubMed=8883409; DOI=10.1038/bjc.1996.521;
RA   Pink J.J., Bilimoria M.M., Assikis V.J., Jordan V.C.;
RT   "Irreversible loss of the oestrogen receptor in T47D breast cancer
RT   cells following prolonged oestrogen deprivation.";
RL   Br. J. Cancer 74:1227-1236(1996).
//