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Cellosaurus ARAC-8C (CVCL_GZ09)

[Text version]

Cell line name ARAC-8C
Synonyms CCRF-CEM-AraC-8C; CEM/ARAC-8C; AraC-8C; Ara-C/8C
Accession CVCL_GZ09
Resource Identification Initiative To cite this cell line use: ARAC-8C (RRID:CVCL_GZ09)
Comments Selected for resistance to: ChEBI; CHEBI:28680; Cytarabine (Arabinosylcytosine; Ara-C).
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Web pages http://icoregon.technologypublisher.com/technology/18057
Publications

PubMed=2842332; DOI=10.1016/S0021-9258(18)37768-8
Ullman B., Coons T., Rockwell S., McCartan K.
Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts.
J. Biol. Chem. 263:12391-12396(1988)

PubMed=18279955; DOI=10.1016/j.leukres.2007.12.015
Huang M., Wang Y., Gu J., Yang J., Noel K., Mitchell B.S., Schramm V.L., Graves L.M.
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H.
Leuk. Res. 32:1268-1278(2008)

Cross-references
Cell line databases/resources TOKU-E; 4127
Other Wikidata; Q54750420
Entry history
Entry creation26-Sep-2016
Last entry update20-May-2021
Version number12