Cellosaurus cell line FM3A tsFT210 (CVCL_H224)

• Mutation; MGI; MGI:88351; Cdk1; Simple; p.Pro272Ser (c.814C>T); Zygosity=Homozygous (PubMed=1903331; PubMed=2208288).
  

PubMed=2428648; DOI=10.1016/0014-4827(86)90203-x
Mineo C., Murakami Y., Ishimi Y., Hanaoka F., Yamada M.-a.
Isolation and analysis of a mammalian temperature-sensitive mutant defective in G2 functions.
Exp. Cell Res. 167:53-62(1986)

PubMed=2208288; DOI=10.1016/0092-8674(90)90164-a
Th'ng J.P.H., Wright P.S., Hamaguchi J., Lee M.G., Norbury C.J., Nurse P., Bradbury E.M.
The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product.
Cell 63:313-324(1990)

PubMed=1903331; DOI=10.1247/csf.16.105
Yasuda H., Kamijo M., Honda R., Nakamura M., Hanaoka F., Ohba Y.
A point mutation in C-terminal region of cdc2 kinase causes a G2-phase arrest in a mouse temperature-sensitive FM3A cell mutant.
Cell Struct. Funct. 16:105-112(1991)

PubMed=1475706; DOI=10.1007/BF01233079
Yasuda H., Nakata T., Kamijo M., Honda R., Nakamura M., Ninomiya-Tsuji J., Yamashita M., Nagahama Y., Ohba Y.
Cyclin-dependent kinase 2 (cdk2) in the murine Cdc2 kinase TS mutant.
Somat. Cell Mol. Genet. 18:403-408(1992)

PubMed=9043671; DOI=10.1016/s0968-0896(96)00207-6
Osada H., Cui C.-B., Onose R., Hanaoka F.
Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210.
Bioorg. Med. Chem. 5:193-203(1997)