Cell line name |
A549/CPT |
Accession |
CVCL_H268 |
Resource Identification Initiative |
To cite this cell line use: A549/CPT (RRID:CVCL_H268) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT). Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
Sequence variations |
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
|
Disease |
Lung adenocarcinoma (NCIt: C3512) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0023 (A-549) |
Sex of cell |
Male |
Age at sampling |
58Y |
Category |
Cancer cell line |
Publications | PubMed=2170010 Sugimoto Y., Tsukahara S., Oh-hara T., Isoe T., Tsuruo T. Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody. Cancer Res. 50:6925-6930(1990) PubMed=2174738 Sugimoto Y., Tsukahara S., Oh-hara T., Liu L.F., Tsuruo T. Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines. Cancer Res. 50:7962-7965(1990) PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2 Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J. Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 64:1403-1410(2004) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_H268
CGH-DB; 9107-4
|
Encyclopedic resources |
Wikidata; Q54607045
|
Entry history |
Entry creation | 11-Feb-2013 |
Last entry update | 05-Oct-2023 |
Version number | 15 |
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