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Cellosaurus MeT-4A (CVCL_H531)

[Text version]
Cell line name MeT-4A
Synonyms MeT 4A; Met4A; Mesothelial cells transfected with pRSV-T 4A
Accession CVCL_H531
Resource Identification Initiative To cite this cell line use: MeT-4A (RRID:CVCL_H531)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pRSV-T].
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Cell type: Mesothelial cell; CL=CL_0000077.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Transformed cell line
Publications

PubMed=2541616
Ke Y., Reddel R.R., Gerwin B.I., Reddel H.K., Somers A.N.A., McMenamin M.G., LaVeck M.A., Stahel R.A., Lechner J.F., Harris C.C.
Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma.
Am. J. Pathol. 134:979-991(1989)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

CLPUB00712
Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references
Encyclopedic resources Wikidata; Q54905321
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number11