Cellosaurus cell line Meso-10 (CVCL_H668)

• Gene deletion; HGNC; 950; BAP1; Zygosity=Heterozygous (PubMed=21642991).
  
• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=21642991).
  

PubMed=16475242; DOI=10.1002/jgm.877
Adusumilli P.S., Stiles B.M., Chan M.-K., Mullerad M., Eisenberg D.P., Ben-Porat L., Huq R., Rusch V.W., Fong Y.-M.
Imaging and therapy of malignant pleural mesothelioma using replication-competent herpes simplex viruses.
J. Gene Med. 8:603-615(2006)

PubMed=21642991; DOI=10.1038/ng.855
Bott M.J., Brevet M., Taylor B.S., Shimizu S., Ito T., Wang L., Creaney J., Lake R.A., Zakowski M.F., Reva B., Sander C., Delsite R., Powell S.N., Zhou Q., Shen R.-L., Olshen A.B., Rusch V.W., Ladanyi M.
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=21774103; DOI=10.1097/JTO.0b013e318215a07d
Brevet M., Shimizu S., Bott M.J., Shukla N., Zhou Q., Olshen A.B., Rusch V.W., Ladanyi M.
Coactivation of receptor tyrosine kinases in malignant mesothelioma as a rationale for combination targeted therapy.
J. Thorac. Oncol. 6:864-874(2011)