ID   HEP G2ins
AC   CVCL_HA60
SY   HEPG2ins; HepG2ins
DR   cancercelllines; CVCL_HA60
DR   Wikidata; Q54882748
RX   Patent=WO1995032740A1;
RX   PubMed=7614254;
RX   PubMed=12958175;
CC   Group: Patented cell line.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 6081; INS.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 14
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RX   Patent=WO1995032740A1;
RA   Tuch B.E., Simpson A.M., Marshall G.M.;
RT   "Transformed human hepatoma cell line which releases insulin.";
RL   Patent number WO1995032740A1, 07-Dec-1995.
//
RX   PubMed=7614254;
RA   Simpson A.M., Tuch B.E., Swan M.A., Tu J., Marshall G.M.;
RT   "Functional expression of the human insulin gene in a human hepatoma
RT   cell line (HEP G2).";
RL   Gene Ther. 2:223-231(1995).
//
RX   PubMed=12958175; DOI=10.1096/fj.02-0051fje;
RA   Liu G.-J., Simpson A.M., Swan M.A., Tao C., Tuch B.E., Crawford R.M.,
RA   Jovanovic A., Martin D.K.;
RT   "ATP-sensitive potassium channels induced in liver cells after
RT   transfection with insulin cDNA and the GLUT 2 transporter regulate
RT   glucose-stimulated insulin secretion.";
RL   FASEB J. 17:1682-1684(2003).
//