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Cellosaurus HUH7-ins (CVCL_HA62)

[Text version]

Cell line name HUH7-ins
Synonyms Huh7ins
Accession CVCL_HA62
Resource Identification Initiative To cite this cell line use: HUH7-ins (RRID:CVCL_HA62)
Comments Population: Japanese.
Characteristics: Secretes insulin in a regulated manner in response to glucose, calcium and theophylline.
Transfected with: HGNC; 6081; INS.
Omics: Transcriptome analysis.
Sequence variations KDR p.Gln472His (c.1416A>T) (from parent cell line).
POLD3 p.Lys70Arg (c.209A>G) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
TP53 p.Tyr220Cys (c.659A>G) (ClinVar=VCV000127819) (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Children:
CVCL_HA63 (Melligen)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=12621453; DOI=10.1038/sj.gt.3301911
Tuch B.E., Szymanska B., Yao M., Tabiin M.T., Gross D.J., Holman S., Swan M.A., Humphrey R.K.B., Marshall G.M., Simpson A.M.
Function of a genetically modified human liver cell line that stores, processes and secretes insulin.
Gene Ther. 10:490-503(2003)

PubMed=21084851; DOI=10.4161/isl.1.1.8994
Lutherborrow M.A., Appavoo M., Simpson A.M., Tuch B.E.
Gene expression profiling of HUH7-ins: lack of a granulogenic function for chromogranin A.
Islets 1:62-74(2009)

Patent=US9365829
Simpson A.M., Tao C.
Cells genetically modified to comprise pancreatic islet glucokinase and uses thereof.
Patent number US9365829, 14-Jun-2016

Cross-references
Other Wikidata; Q54896861
Entry history
Entry creation26-Sep-2016
Last entry update02-Jul-2020
Version number8