ID   HUH7-ins
AC   CVCL_HA62
SY   Huh7ins
DR   cancercelllines; CVCL_HA62
DR   Wikidata; Q54896861
RX   Patent=US10738285;
RX   PubMed=12621453;
RX   PubMed=21084851;
CC   Population: Japanese.
CC   Characteristics: Secretes insulin in a regulated manner in response to glucose, calcium and theophylline.
CC   Sequence variation: Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 6081; INS.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 16
//
RX   Patent=US10738285;
RA   Simpson A.M., Tao C.;
RT   "Cells genetically modified to comprise pancreatic islet glucokinase
RT   and uses thereof.";
RL   Patent number US10738285, 11-Aug-2020.
//
RX   PubMed=12621453; DOI=10.1038/sj.gt.3301911;
RA   Tuch B.E., Szymanska B., Yao M., Tabiin M.T., Gross D.J., Holman S.,
RA   Swan M.A., Humphrey R.K.B., Marshall G.M., Simpson A.M.;
RT   "Function of a genetically modified human liver cell line that stores,
RT   processes and secretes insulin.";
RL   Gene Ther. 10:490-503(2003).
//
RX   PubMed=21084851; DOI=10.4161/isl.1.1.8994;
RA   Lutherborrow M.A., Appavoo M., Simpson A.M., Tuch B.E.;
RT   "Gene expression profiling of HUH7-ins: lack of a granulogenic
RT   function for chromogranin A.";
RL   Islets 1:62-74(2009).
//