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Cellosaurus GEM-MIA PaCa-2 (CVCL_HA89)

[Text version]
Cell line name GEM-MIA PaCa-2
Synonyms GEM,MIA PaCa-2
Accession CVCL_HA89
Resource Identification Initiative To cite this cell line use: GEM-MIA PaCa-2 (RRID:CVCL_HA89)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0428 (MIA PaCa-2)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
Publications

PubMed=14508125; DOI=10.1097/00006676-200310000-00004
Togawa A., Ito H., Kimura F., Shimizu H., Ohtsuka M., Shimamura F., Yoshidome H., Katoh A., Miyazaki M.
Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of brefeldin-a on the resistant cell line.
Pancreas 27:220-224(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_HA89
Encyclopedic resources Wikidata; Q54835559
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number12