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Cellosaurus ZP139 (CVCL_HB19)

[Text version]
Cell line name ZP139
Accession CVCL_HB19
Resource Identification Initiative To cite this cell line use: ZP139 (RRID:CVCL_HB19)
Comments Characteristics: Selected using the 9-(1'-pyrene)nonanol/ultraviolet (P9OH/UV) method. P9OH acts as a photosensitizer. Normal cells which can incorporate the fluorescent fatty alcohol into lipids are killed by UV, but mutants who incorporate P9OH poorly are less susceptible to photosensitized killing.
Transfected with: RGD; 61814; Pex2.
Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; UniProtKB; Q920N5; Pex5; Simple; p.Gly530Glu (c.1589G>A) (G480E); Zygosity=Homozygous (PubMed=9418886).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_HB34 (CHOTKa)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=9418886; DOI=10.1128/mcb.18.1.388
Otera H., Okumoto K., Tateishi K., Ikoma Y., Matsuda E., Nishimura M., Tsukamoto T., Osumi T., Ohashi K., Higuchi O., Fujiki Y.
Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.
Mol. Cell. Biol. 18:388-399(1998)

PubMed=11330042; DOI=10.1385/CBB:32:1-3:155
Fujiki Y., Okumoto K., Otera H., Tamura S.
Peroxisome biogenesis and molecular defects in peroxisome assembly disorders.
Cell Biochem. Biophys. 32:155-164(2000)

PubMed=17045664; DOI=10.1016/j.bbamcr.2006.09.012
Fujiki Y., Okumoto K., Kinoshita N., Ghaedi K.
Lessons from peroxisome-deficient Chinese hamster ovary (CHO) cell mutants.
Biochim. Biophys. Acta 1763:1374-1381(2006)

PubMed=23009329; DOI=10.1042/bj20120911
Natsuyama R., Okumoto K., Fujiki Y.
Pex5p stabilizes Pex14p: a study using a newly isolated pex5 CHO cell mutant, ZPEG101.
Biochem. J. 449:195-207(2013)

Cross-references
Encyclopedic resources Wikidata; Q54996025
Entry history
Entry creation01-Dec-2016
Last entry update30-Jan-2024
Version number12