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Cellosaurus MDA-IBC-3 (CVCL_HC47)

Cell line name MDA-IBC-3
Synonyms MDA-IBC3; MDAIBC3; MD Anderson-Inflammatory Breast Cancer-3
Accession CVCL_HC47
Resource Identification Initiative To cite this cell line use: MDA-IBC-3 (RRID:CVCL_HC47)
Comments Characteristics: ER-negative, PR-negative and ERBB2-positive.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Breast inflammatory carcinoma (NCIt: C4001)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=20808935

Markers:
AmelogeninX
CSF1PO12,13
D5S81810,11
D7S8208,12
D13S31711,12
D16S5399,12
TH018
TPOX10,11
vWA18,19

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Publications

PubMed=20808935; DOI=10.1371/journal.pone.0012180
Klopp A.H., Lacerda L., Gupta A., Debeb B.G., Solley T., Li L., Spaeth E., Xu W., Zhang X.-M., Lewis M.T., Reuben J.M., Krishnamurthy S., Ferrari M., Gaspar R., Buchholz T.A., Cristofanilli M., Marini F., Andreeff M., Woodward W.A.
Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells.
PLoS ONE 5:E12180-E12180(2010)

DOI=10.4172/2161-0681.1000119
Robertson F.M., Chu K., Fernandez S.V., Mu Z.-M., Zhang X.-J., Liu H., Boley K.M., Alpaugh R.K., Ye Z.-M., Wright M.C., Luo A.Z., Oraes R., Wu H., Zook M., Barsky S.H., Krishnamurthy S., Cristofanilli M.
Genomic profiling of pre-clinical models of inflammatory breast cancer identifies a signature of epithelial plasticity and suppression of TGFbeta signaling.
J. Clin. Exp. Pathol. 2:119.1-119.11(2012)

PubMed=23784380; DOI=10.1007/s10549-013-2600-4
Fernandez S.V., Robertson F.M., Pei J.-M., Aburto-Chumpitaz L., Mu Z.-M., Chu K., Alpaugh R.K., Huang Y., Cao Y., Ye Z.-M., Cai K.Q., Boley K.M., Klein-Szanto A.J.P., Devarajan K., Addya S., Cristofanilli M.
Inflammatory breast cancer (IBC): clues for targeted therapies.
Breast Cancer Res. Treat. 140:23-33(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3
Prat A., Karginova O., Parker J.S., Fan C., He X.-P., Bixby L.M., Harrell J.C., Roman E., Adamo B., Troester M.A., Perou C.M.
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=35042871; DOI=10.1038/s41523-021-00379-6
Rypens C., Bertucci F., Finetti P., Robertson F.M., Fernandez S.V., Ueno N.T., Woodward W.A., Van Golen K., Vermeulen P., Dirix L., Viens P., Birnbaum D., Devi G.R., Cristofanilli M., Van Laere S.
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC.
NPJ Breast Cancer 8:12.1-12.12(2022)

Cross-references
Encyclopedic resources Wikidata; Q54904575
Gene expression databases ArrayExpress; E-MTAB-11134
GEO; GSM1008922
GEO; GSM1215265
GEO; GSM3145722
Entry history
Entry creation01-Dec-2016
Last entry update29-Jun-2023
Version number8