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Cellosaurus CHO 7PA2 (CVCL_HC66)

[Text version]

Cell line name CHO 7PA2
Synonyms CHO-7PA2; CHO7PA2; 7PA2
Accession CVCL_HC66
Resource Identification Initiative To cite this cell line use: CHO 7PA2 (RRID:CVCL_HC66)
Comments Transfected with: HGNC; 620; APP (isoform APP751 with p.Val717Phe).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line

PubMed=7721886; DOI=10.1074/jbc.270.16.9564
Podlisny M.B., Ostaszewski B.L., Squazzo S.L., Koo E.H., Rydell R.E., Teplow D.B., Selkoe D.J.
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture.
J. Biol. Chem. 270:9564-9570(1995)

PubMed=23948918; DOI=10.3233/JAD-130728
Krako N., Magnifico M.C., Arese M., Meli G., Forte E., Lecci A., Manca A., Giuffre A., Mastronicola D., Sarti P., Cattaneo A.
Characterization of mitochondrial dysfunction in the 7PA2 cell model of Alzheimer's disease.
J. Alzheimers Dis. 37:747-758(2013)

PubMed=24840308; DOI=10.1021/bi5003053
Welzel A.T., Maggio J.E., Shankar G.M., Walker D.E., Ostaszewski B.L., Li S., Klyubin I., Rowan M.J., Seubert P., Walsh D.M., Selkoe D.J.
Secreted amyloid beta-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.
Biochemistry 53:3908-3921(2014)

Other Wikidata; Q54812555
Entry history
Entry creation01-Dec-2016
Last entry updated07-Sep-2018
Version number4