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Cellosaurus HaCaT BHLHE40 (-/-) (CVCL_HD65)

[Text version]

Cell line name HaCaT BHLHE40 (-/-)
Synonyms BHLHE40 (-/-) HACAT; DEC1-/- HaCaT
Accession CVCL_HD65
Resource Identification Initiative To cite this cell line use: HaCaT BHLHE40 (-/-) (RRID:CVCL_HD65)
Comments Knockout cell: Method=Homologous recombination; HGNC; 1046; BHLHE40.
Derived from sampling site: Back; skin; epidermis; keratinocyte.
Sequence variations Heterozygous for TP53 p.His179Tyr (c.535C>T) (ClinVar=VCV000127815) (from parent cell line).
Heterozygous for TP53 p.Arg282Trp (c.843_844CC>TT) (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line

PubMed=11880636; DOI=10.1073/pnas.261714999
Zawel L., Yu J., Torrance C.J., Markowitz S.D., Kinzler K.W., Vogelstein B., Zhou S.
DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.
Proc. Natl. Acad. Sci. U.S.A. 99:2848-2853(2002)

Cell line collections Horizon_Discovery; HD+R01-001
Other Wikidata; Q54872309
Entry history
Entry creation01-Dec-2016
Last entry update12-Jan-2021
Version number6