ID   HaCaT BHLHE40 (-/-)
SY   BHLHE40 (-/-) HACAT; DEC1-/- HaCaT
DR   Horizon_Discovery; HD+R01-001
DR   Wikidata; Q54872309
RX   PubMed=11880636;
CC   Knockout cell: Method=Homologous recombination; HGNC; 1046; BHLHE40.
CC   Sequence variation: Heterozygous for TP53 p.His179Tyr (c.535C>T) (ClinVar=VCV000127815) (from parent cell line).
CC   Sequence variation: Heterozygous for TP53 p.Arg282Trp (c.843_844CC>TT) (from parent cell line).
CC   Derived from sampling site: Back; skin; epidermis; keratinocyte.
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0038 ! HaCaT
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 01-12-16; Last updated: 12-01-21; Version: 6
RX   PubMed=11880636; DOI=10.1073/pnas.261714999;
RA   Zawel L., Yu J., Torrance C.J., Markowitz S.D., Kinzler K.W.,
RA   Vogelstein B., Zhou S.;
RT   "DEC1 is a downstream target of TGF-beta with sequence-specific
RT   transcriptional repressor activities.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2848-2853(2002).