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Cellosaurus HCT 116 CTNNB1(+/-) (CVCL_HD74)

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Cell line name HCT 116 CTNNB1(+/-)
Synonyms CTNNB1 (+/-) HCT116; CTNNB1 WT/- HCT116
Accession CVCL_HD74
Resource Identification Initiative To cite this cell line use: HCT 116 CTNNB1(+/-) (RRID:CVCL_HD74)
Comments Characteristics: In HCT 116 one of the two CTNNB1 alleles has a 3-bp deletion that eliminates S-45. This cell line is KO for the mutant allele.
Knockout cell: Method=Homologous recombination (1 of 2 alleles); HGNC; 2514; CTNNB1.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-ctnnb1-hct116-cell-line-hd-104-009
Publications

PubMed=12060769; DOI=10.1073/pnas.082240999
Chan T.A., Wang Z., Dang L.H., Vogelstein B., Kinzler K.W.
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation.
Proc. Natl. Acad. Sci. U.S.A. 99:8265-8270(2002)

Cross-references
Other Wikidata; Q54881928
Entry history
Entry creation01-Dec-2016
Last entry updated07-Sep-2018
Version number6