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Cellosaurus HCT 116 FBXW7(-/-) (CVCL_HD78)

[Text version]

Cell line name HCT 116 FBXW7(-/-)
Synonyms FBXW7 (-/-) HCT116; HCT116 hCDC4 -/-
Accession CVCL_HD78
Resource Identification Initiative To cite this cell line use: HCT 116 FBXW7(-/-) (RRID:CVCL_HD78)
Comments Knockout cell: Method=Homologous recombination; HGNC; 16712; FBXW7.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (ClinVar=VCV000017576) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-fbxw7-hct116-cell-line-hd-r02-013

PubMed=14999283; DOI=10.1038/nature02313
Rajagopalan H., Jallepalli P.V., Rago C., Velculescu V.E., Kinzler K.W., Vogelstein B., Lengauer C.
Inactivation of hCDC4 can cause chromosomal instability.
Nature 428:77-81(2004)

Other Wikidata; Q54881939
Entry history
Entry creation01-Dec-2016
Last entry update02-Jul-2020
Version number6