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Cellosaurus HCT 116 PTTG1(-/-) (CVCL_HD93)

[Text version]

Cell line name HCT 116 PTTG1(-/-)
Synonyms PTTG1 (-/-) HCT116; hSecurin-/- HCT116
Accession CVCL_HD93
Resource Identification Initiative To cite this cell line use: HCT 116 PTTG1(-/-) (RRID:CVCL_HD93)
Comments Knockout cell: Method=Homologous recombination; HGNC; 9690; PTTG1.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-pttg1-hct116-cell-line-hd-r02-043
Publications

PubMed=11371342; DOI=10.1016/S0092-8674(01)00340-3
Jallepalli P.V., Waizenegger I.C., Bunz F., Langer S., Speicher M.R., Peters J.-M., Kinzler K.W., Vogelstein B., Lengauer C.
Securin is required for chromosomal stability in human cells.
Cell 105:445-457(2001)

PubMed=16292982; DOI=10.1371/journal.pbio.0030416
Pfleghaar K., Heubes S., Cox J., Stemmann O., Speicher M.R.
Securin is not required for chromosomal stability in human cells.
PLoS Biol. 3:E416-E416(2005)

Cross-references
Other Wikidata; Q54881981
Entry history
Entry creation01-Dec-2016
Last entry updated07-Sep-2018
Version number5