ID   HCT 116 PTTG1(-/-)
AC   CVCL_HD93
SY   PTTG1 (-/-) HCT116; hSecurin-/- HCT116
DR   Wikidata; Q54881981
RX   PubMed=11371342;
RX   PubMed=16292982;
WW   https://www.horizondiscovery.com/human-pttg1-hct116-cell-line-hd-r02-043
CC   Knockout cell: Method=Homologous recombination; HGNC; 9690; PTTG1.
CC   Sequence variation: Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
CC   Sequence variation: Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
CC   Sequence variation: Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
CC   Sequence variation: Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (from parent cell line).
CC   Sequence variation: Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
CC   Sequence variation: Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
CC   Sequence variation: Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 07-09-18; Version: 5
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RX   PubMed=11371342; DOI=10.1016/S0092-8674(01)00340-3;
RA   Jallepalli P.V., Waizenegger I.C., Bunz F., Langer S., Speicher M.R.,
RA   Peters J.-M., Kinzler K.W., Vogelstein B., Lengauer C.;
RT   "Securin is required for chromosomal stability in human cells.";
RL   Cell 105:445-457(2001).
//
RX   PubMed=16292982; DOI=10.1371/journal.pbio.0030416;
RA   Pfleghaar K., Heubes S., Cox J., Stemmann O., Speicher M.R.;
RT   "Securin is not required for chromosomal stability in human cells.";
RL   PLoS Biol. 3:E416-E416(2005).
//