ID   HCT 116 PTTG1(-/-)
AC   CVCL_HD93
SY   PTTG1 (-/-) HCT116; hSecurin-/- HCT116
DR   cancercelllines; CVCL_HD93
DR   Horizon_Discovery; HD+R02-043
DR   Wikidata; Q54881981
RX   PubMed=11371342;
RX   PubMed=16292982;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 9690; PTTG1.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 12
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RX   PubMed=11371342; DOI=10.1016/S0092-8674(01)00340-3;
RA   Jallepalli P.V., Waizenegger I.C., Bunz F., Langer S., Speicher M.R.,
RA   Peters J.-M., Kinzler K.W., Vogelstein B., Lengauer C.;
RT   "Securin is required for chromosomal stability in human cells.";
RL   Cell 105:445-457(2001).
//
RX   PubMed=16292982; DOI=10.1371/journal.pbio.0030416;
RA   Pfleghaar K., Heubes S., Cox J., Stemmann O., Speicher M.R.;
RT   "Securin is not required for chromosomal stability in human cells.";
RL   PLoS Biol. 3:e416.2127-e416.2134(2005).
//