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Cellosaurus HCT 116 SFN(-/-) (CVCL_HD94)

[Text version]

Cell line name HCT 116 SFN(-/-)
Synonyms SFN (-/-) HCT116; 14-3-3s-/- HCT116; 14-3-3sigma-/- HCT116
Accession CVCL_HD94
Resource Identification Initiative To cite this cell line use: HCT 116 SFN(-/-) (RRID:CVCL_HD94)
Comments Knockout cell: Method=Homologous recombination; HGNC; 10773; SFN.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-sfn-hct116-cell-line-hd-r02-001

PubMed=10524633; DOI=10.1038/44188
Chan T.A., Hermeking H., Lengauer C., Kinzler K.W., Vogelstein B.
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
Nature 401:616-620(1999)

Other Wikidata; Q54881982
Entry history
Entry creation01-Dec-2016
Last entry updated07-Sep-2018
Version number5