Home  |  Contact

Cellosaurus HCT 116 USP7(-/-) (CVCL_HD99)

[Text version]

Cell line name HCT 116 USP7(-/-)
Synonyms USP7 (-/-) HCT116; HAUSP-/- HCT116
Accession CVCL_HD99
Resource Identification Initiative To cite this cell line use: HCT 116 USP7(-/-) (RRID:CVCL_HD99)
Comments Knockout cell: Method=Homologous recombination; HGNC; 12630; USP7.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for BRCA2 p.Ile2675fs*6 (c.8021_8022insA) (from parent cell line).
Heterozygous for CDKN2A p.Arg24fs*20 (c.68_69insG) and p.Glu74fs*15 (c.220delG) (from parent cell line).
Heterozygous for CTNNB1 p.Ser45del (c.133_135delTCT) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0291 (HCT 116)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-usp7-hct116-cell-line-hd-r02-028

PubMed=15118411; DOI=10.4161/cc.3.6.924
Cummins J.M., Vogelstein B.
HAUSP is required for p53 destabilization.
Cell Cycle 3:689-692(2004)

Other Wikidata; Q54881991
Entry history
Entry creation01-Dec-2016
Last entry updated07-Sep-2018
Version number5