ID   HCT 116 USP7(-/-)
AC   CVCL_HD99
SY   USP7 (-/-) HCT116; HAUSP-/- HCT116; HCT-116 USP7-null
DR   cancercelllines; CVCL_HD99
DR   Horizon_Discovery; HD+R02-028
DR   Wikidata; Q54881991
RX   PubMed=15118411;
RX   PubMed=29045385;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 12630; USP7.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 13
//
RX   PubMed=15118411; DOI=10.4161/cc.3.6.924;
RA   Cummins J.M., Vogelstein B.;
RT   "HAUSP is required for p53 destabilization.";
RL   Cell Cycle 3:689-692(2004).
//
RX   PubMed=29045385; DOI=10.1038/nature24006;
RA   Kategaya L., Di Lello P., Rouge L., Pastor R., Clark K.R.,
RA   Drummond J., Kleinheinz T., Lin E., Upton J.-P., Prakash S.,
RA   Heideker J., McCleland M.L., Ritorto M.S., Alessi D.R., Trost M.,
RA   Bainbridge T.W., Kwok M.C.M., Ma T.P., Stiffler Z., Brasher B.,
RA   Tang Y.-Y., Jaishankar P., Hearn B.R., Renslo A.R., Arkin M.R.,
RA   Cohen F., Yu K.-B., Peale F.V., Gnad F., Chang M.T., Klijn C.,
RA   Blackwood E., Martin S.E., Forrest W.F., Ernst J.A., Ndubaku C.,
RA   Wang X.-J., Beresini M.H., Tsui V., Schwerdtfeger C., Blake R.A.,
RA   Murray J., Maurer T., Wertz I.E.;
RT   "USP7 small-molecule inhibitors interfere with ubiquitin binding.";
RL   Nature 550:534-538(2017).
//