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Cellosaurus KMS-11 WHSC1(+/-) (CVCL_HE02)

[Text version]

Cell line name KMS-11 WHSC1(+/-)
Synonyms WHSC1 (+/-) KMS-11; KMS-11 MMSET T-KO; KMS-11/TKO; KMS11/TKO; TKO
Accession CVCL_HE02
Resource Identification Initiative To cite this cell line use: KMS-11 WHSC1(+/-) (RRID:CVCL_HE02)
Comments Characteristics: Produces IgG kappa.
Characteristics: In KMS-11 one of the two WHSC1 alleles is translocated. This cell line is KO for the translocated allele.
Knockout cell: Method=Homologous recombination (1 of 2 alleles); HGNC; 12766; WHSC1.
Derived from sampling site: Pleural effusion.
Sequence variations FGFR3 p.Tyr373Cys (c.1118A>G) (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/whsc1-kms-11-cell-line-hd-108-002

PubMed=17942756; DOI=10.1182/blood-2007-05-088674
Lauring J., Abukhdeir A.M., Konishi H., Garay J.P., Gustin J.P., Wang Q., Arceci R.J., Matsui W., Park B.H.
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.
Blood 111:856-864(2008)

Ontologies BTO; BTO:0005876
Other Wikidata; Q54900163