ID   KMS-11 WHSC1(+/-)
AC   CVCL_HE02
SY   WHSC1 (+/-) KMS-11; KMS-11 MMSET T-KO; KMS-11/TKO; KMS11/TKO; TKO
DR   BTO; BTO:0005876
DR   cancercelllines; CVCL_HE02
DR   Horizon_Discovery; HD+108-002
DR   Wikidata; Q54900163
RX   PubMed=17942756;
CC   Population: Japanese.
CC   Characteristics: Produces IgG kappa.
CC   Characteristics: In KMS-11 one of the two WHSC1 alleles is translocated. This cell line is KO for the translocated allele.
CC   Knockout cell: Method=Homologous recombination; HGNC; 12766; NSD2 (Note=1 of 2 alleles).
CC   Sequence variation: Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2989 ! KMS-11
SX   Female
AG   67Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 14
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RX   PubMed=17942756; DOI=10.1182/blood-2007-05-088674;
RA   Lauring J., Abukhdeir A.M., Konishi H., Garay J.P., Gustin J.P.,
RA   Wang Q., Arceci R.J., Matsui W., Park B.H.;
RT   "The multiple myeloma associated MMSET gene contributes to cellular
RT   adhesion, clonogenic growth, and tumorigenicity.";
RL   Blood 111:856-864(2008).
//