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Cellosaurus NALM-6 XRCC5(+/-) (CVCL_HE13)

[Text version]

Cell line name NALM-6 XRCC5(+/-)
Synonyms XRCC5 (+/-) NALM-6; Ku86+/- NALM-6
Accession CVCL_HE13
Resource Identification Initiative To cite this cell line use: NALM-6 XRCC5(+/-) (RRID:CVCL_HE13)
Comments Knockout cell: Method=Homologous recombination (1 of 2 alleles); HGNC; 12833; XRCC5.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for EGFR p.Arg1068Ter (c.3202C>T) (from parent cell line).
Heterozygous for NRAS p.Ala146Thr (c.436G>A) (from parent cell line).
Heterozygous for RARA p.Gln45Ter (c.133C>T) (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-xrcc5-nalm-6-cell-line-hd-115-102

PubMed=18387344; DOI=10.1016/j.dnarep.2008.02.008
Fattah K.R., Ruis B.L., Hendrickson E.A.
Mutations to Ku reveal differences in human somatic cell lines.
DNA Repair 7:762-774(2008)

PubMed=18562296; DOI=10.1073/pnas.0712060105
Fattah F.J., Lichter N.F., Fattah K.R., Oh S., Hendrickson E.A.
Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells.
Proc. Natl. Acad. Sci. U.S.A. 105:8703-8708(2008)

Other Wikidata; Q54907436
Entry history
Entry creation01-Dec-2016
Last entry updated06-Sep-2019
Version number5