ID   NALM-6 XRCC5(+/-)
AC   CVCL_HE13
SY   XRCC5 (+/-) NALM-6; Ku86+/- NALM-6
DR   cancercelllines; CVCL_HE13
DR   Horizon_Discovery; HD+115-102
DR   Wikidata; Q54907436
RX   PubMed=18387344;
RX   PubMed=18562296;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 12833; XRCC5 (Note=1 of 2 alleles).
CC   Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0092 ! NALM-6
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 14
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RX   PubMed=18387344; DOI=10.1016/j.dnarep.2008.02.008;
RA   Fattah K.R., Ruis B.L., Hendrickson E.A.;
RT   "Mutations to Ku reveal differences in human somatic cell lines.";
RL   DNA Repair 7:762-774(2008).
//
RX   PubMed=18562296; DOI=10.1073/pnas.0712060105;
RA   Fattah F.J., Lichter N.F., Fattah K.R., Oh S., Hendrickson E.A.;
RT   "Ku70, an essential gene, modulates the frequency of rAAV-mediated
RT   gene targeting in human somatic cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:8703-8708(2008).
//