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Cellosaurus Panc 04.03 MAP2K4(-/-) (CVCL_HE14)

[Text version]

Cell line name Panc 04.03 MAP2K4(-/-)
Synonyms MAP2K4 (-/-) Panc 04.03; MKK4-/- cells
Accession CVCL_HE14
Resource Identification Initiative To cite this cell line use: Panc 04.03 MAP2K4(-/-) (RRID:CVCL_HE14)
Comments Knockout cell: Method=Homologous recombination; HGNC; 6844; MAP2K4.
Sequence variations ATG7-RAF1 gene fusion (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Homozygous for TP53 p.Gly245Ser (c.733G>A) (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1636 (Panc 04.03)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Web pages https://www.horizondiscovery.com/human-map2k4-panc-04-03-cell-lines-hd-109-002

PubMed=16740690; DOI=10.1158/0008-5472.CAN-06-0555
Cunningham S.C., Gallmeier E., Hucl T., Dezentje D.A., Calhoun E.S., Falco G., Abdelmohsen K., Gorospe M., Kern S.E.
Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.
Cancer Res. 66:5560-5564(2006)

Other Wikidata; Q54937519
Entry history
Entry creation01-Dec-2016
Last entry updated05-Jul-2019
Version number4