ID   Panc 04.03 MAP2K4(-/-)
AC   CVCL_HE14
SY   MAP2K4 (-/-) Panc 04.03; MKK4-/- cells
DR   Wikidata; Q54937519
RX   PubMed=16740690;
WW   https://www.horizondiscovery.com/human-map2k4-panc-04-03-cell-lines-hd-109-002
CC   Knockout cell: Method=Homologous recombination; HGNC; 6844; MAP2K4.
CC   Sequence variation: ATG7-RAF1 gene fusion (from parent cell line).
CC   Sequence variation: Heterozygous for KRAS p.Gly12Asp (c.35G>A) (from parent cell line).
CC   Sequence variation: Homozygous for TP53 p.Gly245Ser (c.733G>A) (from parent cell line).
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1636 ! Panc 04.03
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-07-19; Version: 4
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RX   PubMed=16740690; DOI=10.1158/0008-5472.CAN-06-0555;
RA   Cunningham S.C., Gallmeier E., Hucl T., Dezentje D.A., Calhoun E.S.,
RA   Falco G., Abdelmohsen K., Gorospe M., Kern S.E.;
RT   "Targeted deletion of MKK4 in cancer cells: a detrimental phenotype
RT   manifests as decreased experimental metastasis and suggests a
RT   counterweight to the evolution of tumor-suppressor loss.";
RL   Cancer Res. 66:5560-5564(2006).
//