ID   Panc 04.03 MAP2K4(-/-)
AC   CVCL_HE14
SY   MAP2K4 (-/-) Panc 04.03; MKK4-/- cells
DR   cancercelllines; CVCL_HE14
DR   Horizon_Discovery; HD+109-002
DR   Wikidata; Q54937519
RX   PubMed=16740690;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 6844; MAP2K4.
CC   Sequence variation: Gene fusion; HGNC; 16935; ATG7 + HGNC; 9829; RAF1; Name(s)=ATG7-RAF1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556fs*3 (c.4660_4661insA) (E1554fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1636 ! Panc 04.03
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 10
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RX   PubMed=16740690; DOI=10.1158/0008-5472.CAN-06-0555;
RA   Cunningham S.C., Gallmeier E., Hucl T., Dezentje D.A., Calhoun E.S.,
RA   Falco G., Abdelmohsen K., Gorospe M., Kern S.E.;
RT   "Targeted deletion of MKK4 in cancer cells: a detrimental phenotype
RT   manifests as decreased experimental metastasis and suggests a
RT   counterweight to the evolution of tumor-suppressor loss.";
RL   Cancer Res. 66:5560-5564(2006).
//