Home  |  Contact

Cellosaurus RKO FANCC(+/-/-) (CVCL_HE19)

[Text version]
Cell line name RKO FANCC(+/-/-)
Synonyms FANCC (+/-/-) RKO
Accession CVCL_HE19
Resource Identification Initiative To cite this cell line use: RKO FANCC(+/-/-) (RRID:CVCL_HE19)
Comments Characteristics: RKO carries a stable triplication of the FANCC gene.
Knockout cell: Method=Homologous recombination; HGNC; 3584; FANCC (Note=1 of 3 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016
Gallmeier E., Calhoun E.S., Rago C., Brody J.R., Cunningham S.C., Hucl T., Gorospe M., Kohli M., Lengauer C., Kern S.E.
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 130:2145-2154(2006)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R05-004
Cell line databases/resources cancercelllines; CVCL_HE19
Encyclopedic resources Wikidata; Q54950549
Entry history
Entry creation01-Dec-2016
Last entry update30-Jan-2024
Version number12